Tribe: Joliffieae
  Subtribe Thladianthinae
   Baijiania
   Indofevillea
   Sinobaijiania
   Siraitia [luo han guo]
   Thladiantha [red hail stone]
   Momordica [bitter melon, balsam apple]
  Subtribe Telfairiinae
   Telfairia [fluted pumpkin, oyster nut]
   Odosicyos

  Tribe: Bryonieae
   Bryonia [bryony]
   Ecballium [squirting cucumber]

  Tribe: Trichosantheae
  Subtribe Hodgsoniinae
   Hodgsonia [lard fruit]
  Subtribe Ampelosicyinae
   Ampelosicyos
   Tricyclandra
  Subtribe Trichosanthinae
   Gymnopetalum
   Trichosanthes [snake gourd, pointed gourd]

  Tribe: Herpetospermeae
   Biswarea
   Herpetospermum
   Edgaria

  Tribe: Schizopeponeae
   Schizopepon

  Tribe: Luffeae
   Luffa [loofah]

  Tribe: Sicyeae
  Subtribe Cyclantherinae
   Hanburia
   Echinopepon
   Marah [manroot]
   Echinocystis [prickly cucumber]
   Vaseyanthus
   Brandegea [starvine]
   Elateriopsis
   Pseudocyclanthera
   Cyclanthera [achocha]
   Cremastopus
   Rytidostylis
  Subtribe Sicyinae
   Sicyos [burr cucumber]
   Sicyosperma
   Parasicyos
   Microsechium [chayotillo]
   Sechium [chayote]
   Sechiopsis
   Pterosicyos

  Tribe: Coniandreae
   Kedrostis
   Dendrosicyos
   Corallocarpus
   Ibervillea
   Tumamoca
   Halosicyos
   Ceratosanthes
   Doyerea [coralfruit]
   Trochomeriopsis
   Seyrigia
   Cucurbitella
   Apodanthera [melón loco]
   Guraniopsis
   Melothrianthus
   Wilbrandia
   Helmontia
   Psiguria
   Gurania